A dynamic T cell–limited checkpoint regulates affinity-dependent B cell entry into the germinal center

The germinal center (GC) reaction is essential for the generation of the somatically hypermutated, high-affinity antibodies that mediate adaptive immunity. Entry into the GC is limited to a small number of B cell clones; however, the process by which this limited number of clones is selected is uncl...

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Bibliographic Details
Main Authors: Schwickert, Tanja A., Victora, Gabriel D., Fooksman, David R., Kamphorst, Alice O., Mugnier, Monica R., Gitlin, Alexander D., Dustin, Michael L., Nussenzweig, Michel C.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173244/
https://ncbi.nlm.nih.gov/pubmed/21576382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20102477
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