Germinal Center Dynamics Revealed by Multiphoton Microscopy Using a Photoactivatable Fluorescent Reporter

The germinal center (GC) reaction produces high-affinity antibodies by random mutation and selective clonal expansion of B cells with high-affinity receptors. However, the mechanism by which B cells are selected remains unclear, as does the role of the two anatomically-defined areas of the GC, light...

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Bibliographic Details
Main Authors: Victora, Gabriel D., Schwickert, Tanja A., Fooksman, David R., Kamphorst, Alice O., Meyer-Hermann, Michael, Dustin, Michael L., Nussenzweig, Michel C.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035939/
https://ncbi.nlm.nih.gov/pubmed/21074050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.10.032
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