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Antibody affinity shapes the choice between memory and germinal center B cell fates

Immunological memory is required for protection against repeated infections and is the basis of all effective vaccines. Antibodies produced by memory B cells play an essential role in many of these responses. We have combined lineage tracing with antibody cloning from single B cells to examine the r...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Viant, Charlotte, Weymar, Georg H. J., Escolano, Amelia, Chen, Spencer, Hartweger, Harald, Cipolla, Melissa, Gazumayan, Anna, Nussenzweig, Michel C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7722471/
https://ncbi.nlm.nih.gov/pubmed/33125897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.09.063
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