Improving CNS Delivery to Brain Metastases by Blood-Tumor Barrier Disruption

Brain metastases encompass nearly 80% of all intracranial tumors. A late stage diagnosis confers a poor prognosis, with patients typically surviving less than two years. Poor survival can be equated to limited effective treatment modalities. One reason for the failure rates is the presence of the bl...

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Veröffentlicht in:Trends Cancer
Hauptverfasser: Sprowls, Samuel A., Arsiwala, Tasneem A., Bumgarner, Jacob R., Shah, Neal, Lateef, Sundus S., Kielkowski, Brooke N., Lockman, Paul R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703178/
https://ncbi.nlm.nih.gov/pubmed/31421906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trecan.2019.06.003
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