A Review of Mathematics Determining Solute Uptake at the Blood–Brain Barrier in Normal and Pathological Conditions

The blood–brain barrier (BBB) limits movement of solutes from the lumen of the brain microvascular capillary system into the parenchyma. The unidirectional transfer constant, K(in), is the rate at which transport across the BBB occurs for individual molecules. Single and multiple uptake experiments...

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發表在:Pharmaceutics
Main Authors: Sprowls, Samuel A., Saralkar, Pushkar, Arsiwala, Tasneem, Adkins, Christopher E., Blethen, Kathryn E., Pizzuti, Vincenzo J., Shah, Neal, Fladeland, Ross, Lockman, Paul R.
格式: Artigo
語言:Inglês
出版: MDPI 2021
主題:
Review
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8160855/
https://ncbi.nlm.nih.gov/pubmed/34069733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13050756
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