Hypomethylating Agent Azacitidine Is Effective in Treating Brain Metastasis Triple-Negative Breast Cancer Through Regulation of DNA Methylation of Keratin 18 Gene

Breast cancer patients presenting with symptomatic brain metastases have poor prognosis, and current chemotherapeutic agents are largely ineffective. In this study, we evaluated the hypomethylating agent azacitidine (AZA) for its potential as a novel therapeutic in preclinical models of brain metast...

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Detalhes bibliográficos
Publicado no:Transl Oncol
Main Authors: Butler, Christopher, Sprowls, Samuel, Szalai, Gabor, Arsiwala, Tasneem, Saralkar, Pushkar, Straight, Benjamin, Hatcher, Shea, Tyree, Evan, Yost, Michael, Kohler, William J., Wolff, Benjamin, Putnam, Emily, Lockman, Paul, Liu, Tuoen
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2020
Assuntos:
Review article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225776/
https://ncbi.nlm.nih.gov/pubmed/32408199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100775
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