Hypomethylating Agent Azacitidine Is Effective in Treating Brain Metastasis Triple-Negative Breast Cancer Through Regulation of DNA Methylation of Keratin 18 Gene

Breast cancer patients presenting with symptomatic brain metastases have poor prognosis, and current chemotherapeutic agents are largely ineffective. In this study, we evaluated the hypomethylating agent azacitidine (AZA) for its potential as a novel therapeutic in preclinical models of brain metast...

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Vydáno v:Transl Oncol
Hlavní autoři: Butler, Christopher, Sprowls, Samuel, Szalai, Gabor, Arsiwala, Tasneem, Saralkar, Pushkar, Straight, Benjamin, Hatcher, Shea, Tyree, Evan, Yost, Michael, Kohler, William J., Wolff, Benjamin, Putnam, Emily, Lockman, Paul, Liu, Tuoen
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press 2020
Témata:
Review article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225776/
https://ncbi.nlm.nih.gov/pubmed/32408199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100775
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