Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood–tumor barrier disruption

Blood–brain/blood–tumor barriers (BBB and BTB) and interstitial transport may constitute major obstacles to the transport of therapeutics in brain tumors. In this study, we examined the impact of focused ultrasound (FUS) in combination with microbubbles on the transport of two relevant chemotherapy-...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Arvanitis, Costas D., Askoxylakis, Vasileios, Guo, Yutong, Datta, Meenal, Kloepper, Jonas, Ferraro, Gino B., Bernabeu, Miguel O., Fukumura, Dai, McDannold, Nathan, Jain, Rakesh K.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2018
Предметы:
PNAS Plus
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140479/
https://ncbi.nlm.nih.gov/pubmed/30150398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807105115
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