MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner

MALT1 is a central signaling component in innate and adaptive immunity by regulating NF-κB and other key signaling pathways in different cell types. Activities of MALT1 are mediated by its scaffold and protease functions. Because of its role in lymphocyte activation and proliferation, inhibition of...

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Udgivet i:Front Immunol
Main Authors: Demeyer, Annelies, Skordos, Ioannis, Driege, Yasmine, Kreike, Marja, Hochepied, Tino, Baens, Mathijs, Staal, Jens, Beyaert, Rudi
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6702287/
https://ncbi.nlm.nih.gov/pubmed/31474984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01898
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