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Long-Term MALT1 Inhibition in Adult Mice Without Severe Systemic Autoimmunity

The protease MALT1 is a key regulator of NF-κB signaling and a novel therapeutic target in autoimmunity and cancer. Initial enthusiasm supported by preclinical results with MALT1 inhibitors was tempered by studies showing that germline MALT1 protease inactivation in mice results in reduced regulator...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Demeyer, Annelies, Driege, Yasmine, Skordos, Ioannis, Coudenys, Julie, Lemeire, Kelly, Elewaut, Dirk, Staal, Jens, Beyaert, Rudi
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7522757/
https://ncbi.nlm.nih.gov/pubmed/33083726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101557
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