T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1

The paracaspase mucosa-associated lymphoid tissue 1 (MALT1) is central to lymphocyte activation and lymphomagenesis. MALT1 mediates antigen receptor signalling to NF-κB by acting as a scaffold protein. Furthermore, MALT1 has proteolytic activity that contributes to optimal NF-κB activation by cleavi...

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Bibliografiske detaljer
Main Authors: Staal, Jens, Driege, Yasmine, Bekaert, Tine, Demeyer, Annelies, Muyllaert, David, Van Damme, Petra, Gevaert, Kris, Beyaert, Rudi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101995/
https://ncbi.nlm.nih.gov/pubmed/21448133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.85
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