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Distinct roles of RAD52 and POLQ in chromosomal break repair and replication stress response
Disrupting either the DNA annealing factor RAD52 or the A-family DNA polymerase POLQ can cause synthetic lethality with defects in BRCA1 and BRCA2, which are tumor suppressors important for homology-directed repair of DNA double-strand breaks (DSBs), and protection of stalled replication forks. A li...
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| Publicado no: | PLoS Genet |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6695211/ https://ncbi.nlm.nih.gov/pubmed/31381562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008319 |
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