Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks

Human cancers are characterized by the presence of oncogene-induced DNA replication stress (DRS), making them dependent on repair pathways such as break-induced replication (BIR) for damaged DNA replication forks. To better understand BIR, we performed a targeted siRNA screen for genes whose depleti...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Sotiriou, Sotirios K., Kamileri, Irene, Lugli, Natalia, Evangelou, Konstantinos, Da-Ré, Caterina, Huber, Florian, Padayachy, Laura, Tardy, Sebastien, Nicati, Noemie L., Barriot, Samia, Ochs, Fena, Lukas, Claudia, Lukas, Jiri, Gorgoulis, Vassilis G., Scapozza, Leonardo, Halazonetis, Thanos D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2016
Schlagworte:
Short Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5179496/
https://ncbi.nlm.nih.gov/pubmed/27984746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.10.038
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