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POLD3 is haploinsufficient for DNA replication in mice
The Pold3 gene encodes a subunit of the Polδ DNA polymerase complex. Pold3 orthologues are not essential in Saccharomyces cerevisiae or chicken DT40 cells, but the Schizzosaccharomyces pombe orthologue is essential. POLD3 also has a specialized role in the repair of broken replication forks, suggest...
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| Publicado no: | Mol Cell |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5029548/ https://ncbi.nlm.nih.gov/pubmed/27524497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.07.007 |
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