POLD3 is haploinsufficient for DNA replication in mice

The Pold3 gene encodes a subunit of the Polδ DNA polymerase complex. Pold3 orthologues are not essential in Saccharomyces cerevisiae or chicken DT40 cells, but the Schizzosaccharomyces pombe orthologue is essential. POLD3 also has a specialized role in the repair of broken replication forks, suggest...

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Udgivet i:Mol Cell
Main Authors: Murga, Matilde, Lecona, Emilio, Kamileri, Irene, Díaz, Marcos, Lugli, Natalia, Sotiriou, Sotirios K., Anton, Marta E., Méndez, Juan, Halazonetis, Thanos D., Fernandez-Capetillo, Oscar
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029548/
https://ncbi.nlm.nih.gov/pubmed/27524497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.07.007
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