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Break-induced replication repair of damaged forks induces genomic duplications in human cells
In budding yeast, one-ended DNA double-strand breaks (DSBs) and damaged replication forks are repaired by break-induced replication (BIR), a homologous recombination pathway that requires the Pol32 subunit of DNA polymerase delta. DNA replication stress is prevalent in cancer, but BIR has not been c...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4047655/ https://ncbi.nlm.nih.gov/pubmed/24310611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1243211 |
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