Break-induced replication repair of damaged forks induces genomic duplications in human cells

In budding yeast, one-ended DNA double-strand breaks (DSBs) and damaged replication forks are repaired by break-induced replication (BIR), a homologous recombination pathway that requires the Pol32 subunit of DNA polymerase delta. DNA replication stress is prevalent in cancer, but BIR has not been c...

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Hlavní autoři: Costantino, Lorenzo, Sotiriou, Sotirios K., Rantala, Juha K., Magin, Simon, Mladenov, Emil, Helleday, Thomas, Haber, James E., Iliakis, George, Kallioniemi, Olli, Halazonetis, Thanos D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047655/
https://ncbi.nlm.nih.gov/pubmed/24310611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1243211
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