RNF8 has both KU-dependent and independent roles in chromosomal break repair

Chromosomal double strand breaks (DSBs) can initiate several signaling events, such as ubiquitination, however the precise influence of such signaling on DSB repair outcomes remains poorly understood. With an RNA interference screen, we found that the E3 ubiquitin ligase RNF8 suppresses a deletion r...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Tsai, Linda Jillianne, Lopezcolorado, Felicia Wednesday, Bhargava, Ragini, Mendez-Dorantes, Carlos, Jahanshir, Eva, Stark, Jeremy M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293022/
https://ncbi.nlm.nih.gov/pubmed/32427332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa380
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