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The canonical non-homologous end joining factor XLF promotes chromosomal deletion rearrangements in human cells
Clastogen exposure can result in chromosomal rearrangements, including large deletions and inversions that are associated with cancer development. To examine such rearrangements in human cells, here we developed a reporter assay based on endogenous genes on chromosome 12. Using the RNA-guided nuclea...
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| Yayımlandı: | J Biol Chem |
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| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Biochemistry and Molecular Biology
2020
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6952595/ https://ncbi.nlm.nih.gov/pubmed/31753920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010421 |
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