A BAC Transgene Expressing Human CFTR under Control of Its Regulatory Elements Rescues Cftr Knockout Mice

Small-molecule modulators of cystic fibrosis transmembrane conductance regulator (CFTR) biology show promise in the treatment of cystic fibrosis (CF). A Cftr knockout (Cftr KO) mouse expressing mutants of human CFTR would advance in vivo testing of new modulators. A bacterial artificial chromosome (...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Sci Rep
मुख्य लेखकों: Gawenis, Lara R., Hodges, Craig A., McHugh, Daniel R., Valerio, Dana M., Miron, Alexander, Cotton, Calvin U., Liu, Jinghua, Walker, Nancy M., Strubberg, Ashlee M., Gillen, Austin E., Mutolo, Michael J., Kotzamanis, George, Bosch, Jürgen, Harris, Ann, Drumm, Mitchell L., Clarke, Lane L.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group UK 2019
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6694137/
https://ncbi.nlm.nih.gov/pubmed/31413336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48105-4
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