Cellular chloride and bicarbonate retention alters intracellular pH regulation in Cftr KO crypt epithelium

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR), an anion channel providing a major pathway for Cl(−) and HCO(3)(−) efflux across the apical membrane of the epithelium. In the intestine, CF manifests as obstructive syndromes, dysbiosis, inflammation,...

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Main Authors: Walker, Nancy M., Liu, Jinghua, Stein, Sydney R., Stefanski, Casey D., Strubberg, Ashlee M., Clarke, Lane L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
Assuntos:
Epithelial Biology and Secretion
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719062/
https://ncbi.nlm.nih.gov/pubmed/26542396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00236.2015
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