Cellular chloride and bicarbonate retention alters intracellular pH regulation in Cftr KO crypt epithelium

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR), an anion channel providing a major pathway for Cl(−) and HCO(3)(−) efflux across the apical membrane of the epithelium. In the intestine, CF manifests as obstructive syndromes, dysbiosis, inflammation,...

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Detalles Bibliográficos
Publicado en:Am J Physiol Gastrointest Liver Physiol
Autores principales: Walker, Nancy M., Liu, Jinghua, Stein, Sydney R., Stefanski, Casey D., Strubberg, Ashlee M., Clarke, Lane L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2015
Materias:
Epithelial Biology and Secretion
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719062/
https://ncbi.nlm.nih.gov/pubmed/26542396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00236.2015
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