Cellular chloride and bicarbonate retention alters intracellular pH regulation in Cftr KO crypt epithelium

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR), an anion channel providing a major pathway for Cl(−) and HCO(3)(−) efflux across the apical membrane of the epithelium. In the intestine, CF manifests as obstructive syndromes, dysbiosis, inflammation,...

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Detaylı Bibliyografya
Yayımlandı:Am J Physiol Gastrointest Liver Physiol
Asıl Yazarlar: Walker, Nancy M., Liu, Jinghua, Stein, Sydney R., Stefanski, Casey D., Strubberg, Ashlee M., Clarke, Lane L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2015
Konular:
Epithelial Biology and Secretion
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719062/
https://ncbi.nlm.nih.gov/pubmed/26542396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00236.2015
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