Cellular chloride and bicarbonate retention alters intracellular pH regulation in Cftr KO crypt epithelium

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR), an anion channel providing a major pathway for Cl(−) and HCO(3)(−) efflux across the apical membrane of the epithelium. In the intestine, CF manifests as obstructive syndromes, dysbiosis, inflammation,...

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Publicat a:Am J Physiol Gastrointest Liver Physiol
Autors principals: Walker, Nancy M., Liu, Jinghua, Stein, Sydney R., Stefanski, Casey D., Strubberg, Ashlee M., Clarke, Lane L.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2015
Matèries:
Epithelial Biology and Secretion
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719062/
https://ncbi.nlm.nih.gov/pubmed/26542396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00236.2015
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