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Hesperidin stimulates CFTR-mediated chloride secretion and ciliary beat frequency in sinonasal epithelium

OBJECTIVES: Pharmacologic agents designed to promote mucociliary clearance (MCC) in chronic rhinosinusitis (CRS) represent a novel therapeutic strategy. The objectives of the present study were to investigate whether the natural bioflavonoid hesperidin 1) increases transepithelial chloride (Cl(−)) s...

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Detalhes bibliográficos
Main Authors: Azbell, Christopher, Zhang, Shaoyan, Skinner, Daniel, Fortenberry, James, Sorscher, Eric J., Woodworth, Bradford A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073343/
https://ncbi.nlm.nih.gov/pubmed/20723778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.otohns.2010.05.021
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