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Generation of a conditional null allele for Cftr in mice

The Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene encodes a cAMP-regulated chloride channel that is important in controlling the exchange of fluid and electrolytes across epithelial cells. Mutation of CFTR can lead to Cystic Fibrosis (CF), the most common lethal genetic disease in...

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Detalhes bibliográficos
Main Authors: Hodges, Craig A., Cotton, Calvin U., Palmert, Mark R., Drumm, Mitchell L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711445/
https://ncbi.nlm.nih.gov/pubmed/18802965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvg.20433
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