An Hb-mediated circulating macrophage contributing to pulmonary vascular remodeling in sickle cell disease

Circulating macrophages recruited to the lung contribute to pulmonary vascular remodeling in various forms of pulmonary hypertension (PH). In this study we investigated a macrophage phenotype characterized by intracellular iron accumulation and expression of antioxidant (HO-1), vasoactive (ET-1), an...

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Опубликовано в: :JCI Insight
Главные авторы: Redinus, Katherine, Baek, Jin Hyen, Yalamanoglu, Ayla, Shin, Hye Kyung H., Moldova, Radu, Harral, Julie W., Swindle, Delaney, Pak, David, Ferguson, Scott K., Nuss, Rachelle, Hassell, Kathryn, Nozik-Grayck, Eva, Palmer, Andre F., Fini, Mehdi A., Karoor, Vijaya, Stenmark, Kurt R., Buehler, Paul W., Irwin, David C.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2019
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693838/
https://ncbi.nlm.nih.gov/pubmed/31391342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127860
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