An Hb-mediated circulating macrophage contributing to pulmonary vascular remodeling in sickle cell disease

Circulating macrophages recruited to the lung contribute to pulmonary vascular remodeling in various forms of pulmonary hypertension (PH). In this study we investigated a macrophage phenotype characterized by intracellular iron accumulation and expression of antioxidant (HO-1), vasoactive (ET-1), an...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Redinus, Katherine, Baek, Jin Hyen, Yalamanoglu, Ayla, Shin, Hye Kyung H., Moldova, Radu, Harral, Julie W., Swindle, Delaney, Pak, David, Ferguson, Scott K., Nuss, Rachelle, Hassell, Kathryn, Nozik-Grayck, Eva, Palmer, Andre F., Fini, Mehdi A., Karoor, Vijaya, Stenmark, Kurt R., Buehler, Paul W., Irwin, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693838/
https://ncbi.nlm.nih.gov/pubmed/31391342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127860
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