A polymorphism in the lysyl oxidase propeptide domain accelerates carcinogen-induced cancer

The propeptide (LOX-PP) domain of the lysyl oxidase proenzyme was shown to inhibit the transformed phenotype of breast, lung and pancreatic cells in culture and the formation of Her2/neu-driven breast cancer in a xenograft model. A single nucleotide polymorphism (SNP, rs1800449) positioned in a high...

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Detalles Bibliográficos
Publicado en:Carcinogenesis
Autores principales: de la Cueva, Ana, Emmerling, Michael, Lim, Sarah L, Yang, Shi, Trackman, Philip C, Sonenshein, Gail E, Kirsch, Kathrin H
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
Materias:
Carcinogenesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692853/
https://ncbi.nlm.nih.gov/pubmed/29579155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgy045
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