Lysyl Oxidase Propeptide Sensitizes Pancreatic and Breast Cancer Cells to Doxorubicin-Induced Apoptosis

RAS mutations or its activation by upstream receptor tyrosine kinases are frequently associated with poor response of carcinomas to chemotherapy. The 18 kDa propeptide domain of lysyl oxidase (LOX-PP) released from the secreted precursor protein (Pro-LOX) has been shown to inhibit RAS signaling and...

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Detaylı Bibliyografya
Asıl Yazarlar: Min, Chengyin, Zhao, Yingshe, Romagnoli, Mathilde, Trackman, Philip C., Sonenshein, Gail E., Kirsch, Kathrin H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907072/
https://ncbi.nlm.nih.gov/pubmed/20717927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.22828
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