Inhibition of CIN85-Mediated Invasion by a Novel SH3 Domain Binding Motif in the Lysyl Oxidase Propeptide

The lysyl oxidase gene inhibits Ras signaling in transformed fibroblasts and breast cancer cells. Its activity was mapped to the 162 amino acid propeptide domain (LOX-PP) of the lysyl oxidase precursor protein. LOX-PP inhibited the Her-2/Ras signaling axis in breast cancer cells, and reduced the Her...

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Bibliografische gegevens
Hoofdauteurs: Sato, Seiichi, Zhao, Yingshe, Imai, Misa, Simister, Philip C., Feller, Stephan M., Trackman, Philip C., Kirsch, Kathrin H., Sonenshein, Gail E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2013
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3805583/
https://ncbi.nlm.nih.gov/pubmed/24167568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077288
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