Recombinant Lysyl Oxidase Propeptide Protein Inhibits Growth and Promotes Apoptosis of Pre-Existing Murine Breast Cancer Xenografts

Lysyl oxidase propeptide (LOX-PP) ectopic overexpression inhibits the growth of cancer xenografts. Here the ability and mode of action of purified recombinant LOX-PP (rLOX-PP) protein to inhibit the growth of pre-existing xenografts was determined. Experimental approaches employed were direct intrat...

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Bibliographic Details
Main Authors: Bais, Manish V., Nugent, Matthew A., Stephens, Danielle N., Sume, S. Selva, Kirsch, Kathrin H., Sonenshein, Gail E., Trackman, Philip C.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280126/
https://ncbi.nlm.nih.gov/pubmed/22363577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031188
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