Megakaryocyte polyploidy is inhibited by lysyl oxidase propeptide

Megakaryocytes (MKs), the platelet precursors, undergo an endomitotic cell cycle that leads to polyploidy. Lysyl oxidase propeptide (LOX-PP) is generated from lysyl oxidase (LOX) pro-enzyme after proteolytical cleavage. We recently reported that LOX, a known matrix cross-linking enzyme, contributes...

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Detalhes bibliográficos
Main Authors: Eliades, Alexia, Papadantonakis, Nikolaos, Matsuura, Shinobu, Mi, Rongjuan, Bais, Manish V., Trackman, Philip, Ravid, Katya
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674089/
https://ncbi.nlm.nih.gov/pubmed/23518500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.24312
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