Control of Megakaryocyte Expansion and Bone Marrow Fibrosis by Lysyl Oxidase

Lysyl oxidase (LOX), a matrix cross-linking protein, is known to be selectively expressed and to enhance a fibrotic phenotype. A recent study of ours showed that LOX oxidizes the PDGF receptor-β (PDGFR-β), leading to amplified downstream signaling. Here, we examined the expression and functions of L...

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Hlavní autoři: Eliades, Alexia, Papadantonakis, Nikolaos, Bhupatiraju, Ajoy, Burridge, Kelley A., Johnston-Cox, Hillary A., Migliaccio, Anna Rita, Crispino, John D., Lucero, Hector A., Trackman, Philip C., Ravid, Katya
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149354/
https://ncbi.nlm.nih.gov/pubmed/21665949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.243113
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