CREB Promotes Beta Cell Gene Expression by Targeting Its Coactivators to Tissue-Specific Enhancers

CREB mediates effects of cyclic AMP on cellular gene expression. Ubiquitous CREB target genes are induced following recruitment of CREB and its coactivators to promoter proximal binding sites. We found that CREB stimulates the expression of pancreatic beta cell-specific genes by targeting CBP/p300 t...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Van de Velde, Sam, Wiater, Ezra, Tran, Melissa, Hwang, Yousang, Cole, Philip A., Montminy, Marc
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692124/
https://ncbi.nlm.nih.gov/pubmed/31182641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00200-19
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