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Metabolic engineering of Bacillus megaterium for heparosan biosynthesis using Pasteurella multocida heparosan synthase, PmHS2

BACKGROUND: Heparosan is the unsulfated precursor of heparin and heparan sulfate and its synthesis is typically the first step in the production of bioengineered heparin. In addition to its utility as the starting material for this important anticoagulant and anti-inflammatory drug, heparosan is a v...

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Bibliografske podrobnosti
izdano v:Microb Cell Fact
Main Authors: Williams, Asher, Gedeon, Kamil S., Vaidyanathan, Deepika, Yu, Yanlei, Collins, Cynthia H., Dordick, Jonathan S., Linhardt, Robert J., Koffas, Mattheos A. G.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691538/
https://ncbi.nlm.nih.gov/pubmed/31405374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-019-1187-9
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