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Metabolic engineering of Bacillus megaterium for heparosan biosynthesis using Pasteurella multocida heparosan synthase, PmHS2

BACKGROUND: Heparosan is the unsulfated precursor of heparin and heparan sulfate and its synthesis is typically the first step in the production of bioengineered heparin. In addition to its utility as the starting material for this important anticoagulant and anti-inflammatory drug, heparosan is a v...

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發表在:Microb Cell Fact
Main Authors: Williams, Asher, Gedeon, Kamil S., Vaidyanathan, Deepika, Yu, Yanlei, Collins, Cynthia H., Dordick, Jonathan S., Linhardt, Robert J., Koffas, Mattheos A. G.
格式: Artigo
語言:Inglês
出版: BioMed Central 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691538/
https://ncbi.nlm.nih.gov/pubmed/31405374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-019-1187-9
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