Synthesis and characterization of a long-acting emtricitabine prodrug nanoformulation

PURPOSE: A palmitoylated prodrug of emtricitabine (FTC) was synthesized to extend the drug’s half-life, antiretroviral activities and biodistribution. METHODS: A modified FTC prodrug (MFTC) was synthesized by palmitoyl chloride esterification. MFTC’s chemical structure was evaluated by nuclear magne...

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Bibliografiske detaljer
Udgivet i:Int J Nanomedicine
Main Authors: Ibrahim, Ibrahim M, Bade, Aditya N, Lin, Zhiyi, Soni, Dhruvkumar, Wojtkiewicz, Melinda, Dyavar Shetty, Bhagya Laxmi, Gautam, Nagsen, McMillan, JoEllyn M, Alnouti, Yazen, Edagwa, Benson J, Gendelman, Howard E
Format: Artigo
Sprog:Inglês
Udgivet: Dove 2019
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689761/
https://ncbi.nlm.nih.gov/pubmed/31496683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S215447
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