Development and characterization of a long-acting nanoformulated abacavir prodrug

AIM: A myristoylated abacavir (ABC) prodrug was synthesized to extend drug half-life and bioavailability. METHODS: Myristoylated ABC (MABC) was made by esterifying myristic acid to the drug's 5-hydroxy-cyclopentene group. Chemical composition, antiretroviral activity, cell uptake and retention...

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Опубликовано в: :Nanomedicine (Lond)
Главные авторы: Singh, Dhirender, McMillan, JoEllyn, Hilaire, James, Gautam, Nagsen, Palandri, Diana, Alnouti, Yazen, Gendelman, Howard E, Edagwa, Benson
Формат: Artigo
Язык:Inglês
Опубликовано: Future Medicine Ltd 2016
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4996153/
https://ncbi.nlm.nih.gov/pubmed/27456759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm-2016-0164
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