Pharmacokinetics of a Long-Acting Nanoformulated Dolutegravir Prodrug in Rhesus Macaques

A nanoformulated myristoylated dolutegravir prodrug (NMDTG) was prepared using good laboratory practice protocols. Intramuscular injection of NMDTG (118 ± 8 mg/ml, 25.5 mg of DTG equivalents/kg of body weight) to three rhesus macaques led to plasma DTG levels of 86 ± 12 and 28 ± 1 ng/ml on days 35 a...

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Publicat a:Antimicrob Agents Chemother
Autors principals: McMillan, JoEllyn, Szlachetka, Adam, Slack, Lara, Sillman, Brady, Lamberty, Benjamin, Morsey, Brenda, Callen, Shannon, Gautam, Nagsen, Alnouti, Yazen, Edagwa, Benson, Gendelman, Howard E., Fox, Howard S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2017
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740312/
https://ncbi.nlm.nih.gov/pubmed/29061742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01316-17
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