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SHAPE probing reveals human ribosomal RNAs are largely unfolded in solution

Chemical probing experiments, coupled with empirically-determined free energy change relationships, can enable accurate modeling of the secondary structures of diverse and complex RNAs. A current frontier lies in modeling large and structurally heterogeneous transcripts, including complex eukaryotic...

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Publicado en:Biochemistry
Autores principales: Giannetti, Catherine A., Busan, Steven, Weidmann, Chase A., Weeks, Kevin M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6687064/
https://ncbi.nlm.nih.gov/pubmed/31305988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00076
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