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STIM1 holds a STING in its (N-terminal) tail
The ER Ca(2+) content sensor STIM1 is essential for adaptive immune responses, yet patients with hypomorphic STIM1 mutations develop both immunodeficiency and autoimmunity, implying that STIM1 also restrains immune responses. The study by Srikanth et al [1] elucidated that STIM1 tethers STING, a maj...
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| Pubblicato in: | Cell Calcium |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6686850/ https://ncbi.nlm.nih.gov/pubmed/30922524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2019.03.003 |
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