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STIM1 holds a STING in its (N-terminal) tail

The ER Ca(2+) content sensor STIM1 is essential for adaptive immune responses, yet patients with hypomorphic STIM1 mutations develop both immunodeficiency and autoimmunity, implying that STIM1 also restrains immune responses. The study by Srikanth et al [1] elucidated that STIM1 tethers STING, a maj...

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Bibliografische gegevens
Gepubliceerd in:Cell Calcium
Hoofdauteurs: Son, Aran, de Jesus, Adriana Almeida, Schwartz, Daniella M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6686850/
https://ncbi.nlm.nih.gov/pubmed/30922524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2019.03.003
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