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A sting in the tail: the N-terminal domain of the androgen receptor as a drug target

The role of androgen receptor (AR) in the initiation and progression of prostate cancer (PCa) is well established. Competitive inhibition of the AR ligand-binding domain (LBD) has been the staple of antiandrogen therapies employed to combat the disease in recent years. However, their efficacy has of...

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Publicat a:Asian J Androl
Autors principals: Monaghan, Amy E, McEwan, Iain J
Format: Artigo
Idioma:Inglês
Publicat: Medknow Publications & Media Pvt Ltd 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5000789/
https://ncbi.nlm.nih.gov/pubmed/27212126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/1008-682X.181081
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