Targeting Translation Termination Machinery with Antisense Oligonucleotides for Diseases Caused by Nonsense Mutations

Efforts to develop treatments for diseases caused by nonsense mutations have focused on identification of small molecules that promote translational read-through of messenger RNAs (mRNAs) harboring nonsense stop codons to produce full-length proteins. However, to date, no small molecule read-through...

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Bibliografske podrobnosti
izdano v:Nucleic Acid Ther
Main Authors: Huang, Lulu, Aghajan, Mariam, Quesenberry, Tianna, Low, Audrey, Murray, Susan F., Monia, Brett P., Guo, Shuling
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc., publishers 2019
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6686700/
https://ncbi.nlm.nih.gov/pubmed/31070517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2019.0779
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