Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations

BACKGROUND: About 11% of all human genetic diseases are caused by nonsense mutations that generate premature translation termination codons (PTCs) in messenger RNAs (mRNA). PTCs not only lead to the production of truncated proteins, but also often result in  decreased mRNA abundance due to  nonsense...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Huang, Lulu, Low, Audrey, Damle, Sagar S., Keenan, Melissa M., Kuntz, Steven, Murray, Susan F., Monia, Brett P., Guo, Shuling
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5769327/
https://ncbi.nlm.nih.gov/pubmed/29334995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1386-9
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