Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations

BACKGROUND: About 11% of all human genetic diseases are caused by nonsense mutations that generate premature translation termination codons (PTCs) in messenger RNAs (mRNA). PTCs not only lead to the production of truncated proteins, but also often result in  decreased mRNA abundance due to  nonsense...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Genome Biol
Hlavní autoři: Huang, Lulu, Low, Audrey, Damle, Sagar S., Keenan, Melissa M., Kuntz, Steven, Murray, Susan F., Monia, Brett P., Guo, Shuling
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5769327/
https://ncbi.nlm.nih.gov/pubmed/29334995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1386-9
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky