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Targeting Translation Termination Machinery with Antisense Oligonucleotides for Diseases Caused by Nonsense Mutations

Efforts to develop treatments for diseases caused by nonsense mutations have focused on identification of small molecules that promote translational read-through of messenger RNAs (mRNAs) harboring nonsense stop codons to produce full-length proteins. However, to date, no small molecule read-through...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Nucleic Acid Ther
Main Authors: Huang, Lulu, Aghajan, Mariam, Quesenberry, Tianna, Low, Audrey, Murray, Susan F., Monia, Brett P., Guo, Shuling
פורמט: Artigo
שפה:Inglês
יצא לאור: Mary Ann Liebert, Inc., publishers 2019
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6686700/
https://ncbi.nlm.nih.gov/pubmed/31070517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2019.0779
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