Cell cycle progression in confining microenvironments is regulated by a growth-responsive TRPV4-PI3K/Akt-p27(Kip1) signaling axis

In tissues, cells reside in confining microenvironments, which may mechanically restrict the ability of a cell to double in size as it prepares to divide. How confinement affects cell cycle progression remains unclear. We show that cells progressed through the cell cycle and proliferated when cultur...

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Vydáno v:Sci Adv
Hlavní autoři: Nam, Sungmin, Gupta, Vivek Kumar, Lee, Hong-pyo, Lee, Joanna Y., Wisdom, Katrina M., Varma, Sushama, Flaum, Eliott Marie, Davis, Ciara, West, Robert B., Chaudhuri, Ovijit
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6685709/
https://ncbi.nlm.nih.gov/pubmed/31457089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw6171
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