YAP-independent mechanotransduction drives breast cancer progression

Increased tissue stiffness is a driver of breast cancer progression. The transcriptional regulator YAP is considered a universal mechanotransducer, based largely on 2D culture studies. However, the role of YAP during in vivo breast cancer remains unclear. Here, we find that mechanotransduction occur...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Lee, Joanna Y., Chang, Jessica K., Dominguez, Antonia A., Lee, Hong-pyo, Nam, Sungmin, Chang, Julie, Varma, Sushama, Qi, Lei S., West, Robert B., Chaudhuri, Ovijit
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478686/
https://ncbi.nlm.nih.gov/pubmed/31015465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09755-0
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