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Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments

For mesenchymal stem cells (MSCs) cultured in three dimensional matrices, matrix remodeling is associated with enhanced osteogenic differentiation. However, the mechanism linking matrix remodeling in 3D to osteogenesis of MSCs remains unclear. Here, we find that MSCs in viscoelastic hydrogels exhibi...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Lee, Hong-pyo, Stowers, Ryan, Chaudhuri, Ovijit
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355972/
https://ncbi.nlm.nih.gov/pubmed/30705265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08465-x
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