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Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments
For mesenchymal stem cells (MSCs) cultured in three dimensional matrices, matrix remodeling is associated with enhanced osteogenic differentiation. However, the mechanism linking matrix remodeling in 3D to osteogenesis of MSCs remains unclear. Here, we find that MSCs in viscoelastic hydrogels exhibi...
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| Veröffentlicht in: | Nat Commun |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6355972/ https://ncbi.nlm.nih.gov/pubmed/30705265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08465-x |
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